Art
with a purpose
Claus Bertermann’s artwork is more than just a visual expression—it’s a mission. By purchasing one of his pieces, you’re not only acquiring a unique work of art but also contributing to a meaningful cause.
Metabolic diseases are complex and often life-altering conditions that impact the body’s ability to process energy and essential nutrients. Research is crucial to finding better treatments and, ultimately, a cure. Through his art, Claus Bertermann aims to raise both awareness and funding for this vital cause.
Join him in making a difference—one artwork at a time
METABOLIC DISEASES
What are metabolic diseases?
Metabolic diseases are inherited conditions that affect how the body processes substances needed for growth, energy production, and overall health. Our cells constantly break down and produce various compounds to ensure our body functions properly—this process is called metabolism. Enzymes play a crucial role in this system, acting as tiny “factories” that help convert substances into usable energy and nutrients. These enzymes are produced according to genetic instructions in our DNA.
When a genetic mutation disrupts the production of a specific enzyme, the body either produces too little of it or none at all. As a result, harmful substances accumulate in the body, leading to a wide range of health problems. Metabolic diseases can manifest at any stage of life, from infancy to adulthood, and their severity varies depending on the type of enzyme affected.
Types, causes and impact
There are over 800 different types of inherited metabolic diseases, each caused by the malfunction of a specific enzyme. Because different enzymes process different substances, each disease has its own unique effects on the body. The underlying genetic mutation is typically inherited from both parents.
The symptoms of metabolic diseases can vary widely, even among individuals with the same condition. Some people experience mild symptoms, while others face severe complications affecting multiple organs. Diagnosis and treatment require a team of specialists, including pediatricians, neurologists, geneticists, and researchers. Centers like Erasmus MC play a vital role in advancing research and providing expert care for these rare but serious conditions.
TYPES
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